Each of us cares
about someone

who will need medicines.

Each of us cares about someone
who will need medicines.

Our pipeline.

Program
Therapeutic Area
Indication
Stage of Development
Target
NK3R
GPCR
Program Type
Internal
Overview
ABCL635 is a potential first-in-class investigational antibody drug candidate for the non-hormonal treatment of moderate and severe VMS (commonly known as hot flashes) due to menopause. ABCL635 selectively targets NK3R, a complex transmembrane protein found on hypothalamic KNDy neurons that helps regulate body temperature. ABCL635 is the first AbCellera-led program generated using its GPCR and ion channel technologies to enter the clinic.

ABCL635 is currently being evaluated in a Phase 1/2 study (NCT07118891). Disclosed top-line results from the Phase 2 portion of the study of ABCL635 at week 4 demonstrated significant reductions in both frequency and severity of moderate and severe VMS, a favorable tolerability profile, and significant improvements in sleep and symptom burden compared to placebo.

ABCL635 is also being developed for the treatment of VMS caused by hormone suppression associated with breast and prostate cancer treatment.
Target
NK3R
GPCR
Program Type
Internal
Overview

ABCL635 is an investigational antibody drug candidate being developed for the non-hormonal treatment of VMS (commonly known as hot flashes) due to adjuvant endocrine therapy (AET) for breast cancer. ABCL635 specifically targets NK3R, a complex transmembrane protein found on hypothalamic KNDy neurons that helps regulate body temperature.

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ABCL635 is also being developed for the treatment of VMS due to menopause and VMS due to androgen deprivation therapy (ADT) for prostate cancer.

Target
NK3R
GPCR
Program Type
Internal
Overview

ABCL635 is an investigational antibody drug candidate being developed for the non-hormonal treatment of VMS (commonly known as hot flashes) due to androgen deprivation therapy (ADT) for prostate cancer. ABCL635 specifically targets NK3R, a complex transmembrane protein found on hypothalamic KNDy neurons that helps regulate body temperature.

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ABCL635 is also being developed for the treatment of VMS due to menopause and VMS due to adjuvant endocrine therapy (AET) for breast cancer.

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Target
NK3R
GPCR
Program Type
Internal
Overview

ABCL992 is a next-generation investigational antibody drug being developed for the treatment of moderate and severe VMS. ABCL992 is a half-life extended analog of ABCL635 designed to support less frequent intervals. ABCL992 specifically targets NK3R, a complex transmembrane protein found on hypothalamic KNDy neurons that helps regulate body temperature.

Target
OX40L
Program Type
Internal
Overview
ABCL575 is an investigative monoclonal antibody for the treatment of moderate-to-severe atopic dermatitis (AD), with potential applications to other inflammatory and autoimmune conditions. ABCL575 binds OX40L to disrupt OX40/OX40L signaling, a regulator of inflammatory pathways in AD. It has been engineered with a modified Fc domain to support Fc-silencing and half-life extension.

Top-line results from the Phase 1 clinical trial of ABCL575 demonstrate a favorable tolerability and pharmacokinetic profile that supports an extended dosing interval.

Currently, AbCellera does not intend to pursue further clinical development of ABCL575.
Target
Undisclosed
GPCR / Ion Channel
Program Type
Internal
Overview
ABCL688 is an investigational antibody drug candidate targeting a complex transmembrane protein for the treatment of an undisclosed indication in autoimmunity. ABCL688 is the second AbCellera-led program generated using our GPCR and ion channel technologies to enter IND-enabling activities.

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Target
Undisclosed
Program Type
Internal
Overview
ABCL386 is an investigational antibody drug candidate for the treatment of an undisclosed indication in oncology.
Target
Undisclosed
GPCR/Ion Channel
Program Type
Internal
Overview

ABCL385 is an investigational antibody drug candidate for an undisclosed indication in oncology.

Target
Undisclosed
Ion Channel
Program Type
Internal
Overview

ABCL646 is a potential first-in-class investigational antibody drug candidate for an undisclosed ion channel target and undisclosed indication.

Our Platform

From target to the clinic. Our platform integrates biology, computation, and engineering to develop impactful antibody-based medicines.

People
connected.

This is a place that exists to push the limits of science and technology. A place focused on delivering breakthrough medicines that alleviate suffering, extend lives, and improve health.

With
purpose.

In the end, our success will be measured by the impact of our medicines.

Tiffany Mintah

Learning and Development Program Manager

AbCellera’s commitment to people, teams, and relationships is what drew me towards the company. I’m surrounded by brilliant, kind, and down-to-earth people every day, and I’m excited to contribute to this team.

Allie Goodman

Associate Scientific Director

Our family relocated to Vancouver from Boston — it’s a great place to raise our kids. We’re big hikers, bikers, and skiers, and take every chance we get to drive 25 min to the mountains and go on an adventure!

Peri Selevos

Senior Scientist

I love being part of a team where everyone’s ideas are heard. We work together to solve problems and make things happen, which makes coming to work something I actually look forward to—even on Mondays!

Callum Costello

Scientist I

There’s a tangible impact from the work I do as we move towards bringing medicines to patients. And I get to do that inspirational work in Vancouver, where I’m surrounded by incredible nature!

14+ Years

We have grown from six scientists in a lab to a company of ~600 people with fully integrated capabilities for creating first-in-class and best-in-class antibody medicines.

100+ Programs

Since 2015, we have worked with more than 40 partners on 100+ antibody drug programs, solving some of the most difficult problems in the industry.

One Platform

We have built a competitive advantage in the creation of antibody-based medicines. We are using our technology platform to advance programs involving complex transmembrane proteins, bispecifics, and antibody drug conjugates.

We hire for character and intelligence.

Driven by science.

View our publications.