A rational approach for selecting CD3-binding antibodies for T-cell engager development

Mai M, et al. Society for Immunotherapy of Cancer (SITC) Annual Meeting, November 2023

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This poster describes a data-backed approach for the selection of CD3-binding antibodies for different tumor targets, highlighting that CD3 affinity alone is not sufficient to optimize T-cell engager (TCE) function. Here, we show how this platform was leveraged to generate TCEs for multiple targets, including prostate-specific membrane antigen (PSMA) and melanoma-associated antigen 4 (MAGE-A4).

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