Technology - AbCellera

Maximize the Search Space.

Generate a wide range of diverse antibodies with proprietary immunization strategies and single-cell screening.

REVEAL
Developable Leads.

Express and test hundreds of antibodies with robust characterization and developability assessment. Ruthlessly downselect to functional and developable leads.

Move with Unmatched precision & speed.

Propel programs to the clinic – and to patients – with an optimal development candidate that plugs directly into development pipelines.

Sources

More species.
More diversity.

Direct screening of single B cells eliminates the need for species-specific fusion partners. This opens up a world of possibilities for new therapies.

Humanized platforms

Access a complete functional human antibody repertoire through our Trianni humanized mouse platform, which was generated with proprietary in silico design of antibody genes that resulted in a novel antibody gene structure at the heavy, lambda and kappa mouse antibody loci to maximize antibody diversity.

Different species

Antibodies from alternate species offer unique opportunities for therapeutic development. Access natural immune responses to obtain unprecedented diversity and enable the discovery of therapeutics from any species.

Human antibody discovery

The best humanization strategy is none at all.

Immunizations

Better shots.

Strategic immunizations to drive the immune response.

We work with all target classes, including the most difficult ones. Using creative techniques we drive targeted immune responses towards functional antibodies.

Single-cell screening

Deeply search any antibody response.

More data upfront with customized single-cell assays.

We can comb through millions of enriched antibody-secreting cells in a campaign. With a suite of proprietary microfluidic single-cell assays, we’ll find the rare antibodies with the properties you want.

Looking for a unique property? We’ll design an assay to find it.

Live cell

1/6

Find antibodies that bind a target expressed in its native conformation on a live cell surface. Filter out antibodies that bind unwanted cell surface proteins using multiplexed cell-binding assays.

Specificity

2/6

Find antibodies that bind a specific target or epitope and not other proteins using multiplexed bead-binding assays.

Cross-reactivity

3/6

Screen for antibodies that are cross-reactive for different targets or species using multiplexed bead- and cell-binding assays.

AFFINITY

4/6

Enrich for antibodies with various affinities for a target.

Ligand-Receptor Interactions

5/6

Distinguish between antibodies that block or allow for receptor-ligand interactions.

Combinations

6/6

Find antibodies with rare properties using multiplexed combination cell- and bead-based assays, executed in a stepwise fashion.

Repertoire sequencing

Amplify options.

We combine proprietary repertoire sequencing technologies with functional data from single B cells to annotate immune repertoires and boost the number of candidates.